RFdiffusion3可按原子设计蛋白质，设计的两类酶在实验中实现预期反应
国际联合研究团队公布生成式人工智能系统 RFdiffusion3，可按原子设计蛋白质与核酸；研究成果发表于《科学》。在41个现有酶活性位点的对比测试中，RFdiffusion3有37组表现优于RFdiffusion2，生成蛋白质结构的速度约为后者的十倍。该系统设计的对氧磷降解酶与肽裂解酶在真实实验中完成了预期化学反应。
#合成生物/生物制造
外媒与科技媒体长文、研究号文章
IT之家利好AI 评分6868
MIT Technology ReviewAI 评分1919 Roundtables: A Conversation With the Creator of AI-Designed Viruses
Listen to the session or watch below Can AI design new life forms? In 2025, Stanford University PhD student Samuel King came up with a preliminary answer when he used a generative AI model to propose genetic blueprints for microscopic viruses. It isn’t yet an example of AI-generated life, but that c
The AtlanticAI 评分5858 《大西洋月刊》解析基因治疗核心载体AAV的不可预测风险
文章介绍腺相关病毒（AAV）在基因治疗中的作用及相关风险，并梳理了中国临床试验中的死亡病例、费城一名男孩脑肿瘤病例，以及一名患有Cockayne综合征的男孩接受治疗的经历。AAV可能进入患者基因组；经血液给药时容易到达并积聚于肝脏，不同疗法的病毒颗粒剂量可从每公斤5000亿到300万亿不等。
Fast Company利好AI 评分2929 This startup is turning fallen leaves into biodegradable plastic
First-generation bioplastics were made from food crops like corn and sugar. A new biomaterials startup is using something very different: the autumn leaves collected by cities each fall. The startup, Perennial Polymers, extracts the natural polymers in leaves—lignin and cellulose—to make plastic tha
IT之家AI 评分3838 Colossal 推出 AI 平台 GenoMorph，助力加快复活灭绝物种研究
IT之家 10 月 15 日消息，据 TechCrunch 报道，Colossal Biosciences 于当地时间周三发布了一款全新人工智能平台，助力加快复活灭绝物种的相关研究。据IT之家了解，这款名为 GenoMorph 的平台结合先进三维形态学、比较基因组学与发育生物学技术，在基因数据有限的复活项目中，筛选出可用于基因编辑的目标基因。该公司正借助这个平台推进渡渡鸟复活计划，而渡渡鸟可用的基因组资料十分匮乏。举例来说，公司在猛犸象复活项目中获取了 100 份基因组样本，但渡渡鸟项目仅有一份基因组可用。公司表示，猛犸象生存的寒冷环境更利于保存 DNA，而渡渡鸟栖息在热带地区，因此留存下来的
Fast Company利好AI 评分1414 Colossal has take another big step toward bringing back the Dodo
Since its founding in 2021, Colossal Biosciences has sought to bring back extinct animals, including the Dodo, the iconic flightless bird once endemic to Mauritius. The bird was documented by humans when the Portuguese first arrived on the island in the 16th century, but hasn’t been seen in hundreds
Ars Technica利好AI 评分4949 研究人员利用 AI 设计可切割其他蛋白质的蛋白质
研究人员利用 AI 蛋白质设计工具改造两类蛋白酶的催化核心，设计出可定向切割特定蛋白质的酶。研究人员用它们切割与神经系统疾病相关的蛋白质，展示了其效果。
Fast CompanyAI 评分1919 Former ARPA-H director Renee Wegrzyn wants to solve science’s ‘magic hands’ problem
Renee Wegrzyn spent her career building the future of American science—including the Advanced Research Projects Agency for Health, or ARPA-H, the White House agency created to accelerate health breakthroughs. Then the Trump administration showed her the door. Wegrzyn cofounded Transfyr to tackle wha
MIT Technology ReviewAI 评分1515 Roundtables: A Conversation With the Creator of AI-Designed Viruses
Friday, October 16, 2026 Can AI design new life forms? In 2025, Stanford University PhD student Samuel King came up with a preliminary answer when he used a generative AI model to propose genetic blueprints for microscopic viruses. It isn’t yet an example of AI-generated life, but that could be next
IT之家AI 评分1414 巴西喙莎草有性繁殖却产出克隆后代，科学家发现首例雌雄减数分裂完全无重组的有性物种
IT之家 10 月 4 日消息，德国马克斯 · 普朗克植物育种研究所的安德烈 · 马奎斯（André Marques）领导的一支国际团队发现，巴西喙莎草（Rhynchospora tenuis）虽进行有性繁殖 —— 产生花粉、完成受精并结出种子，却完全丧失了减数分裂中同源染色体之间的 DNA 交换。也就是说，这种植物通过有性生殖产生种子，但在父本和母本染色体之间完全没有 DNA 重组，后代与母本基因型相同，在结果上类似克隆繁殖。相关论文发表在《自然》杂志上。按照大家所学到的中学课本知识，有性繁殖通常依赖减数分裂，同源染色体在这一过程中交换 DNA 片段，产生遗传多样性并确保染色体正确分离。没有
MIT Technology ReviewAI 评分2121 A new contest pits competitors against each other in a race to biological youth
This week, I officially signed up for an unusual competition. One that rewards competitors for getting younger. I recently turned 40, and I don’t need reminding that both time and my chronological age only tick forward. But this game is focused on competitors’ biological ages—figures that are meant